Noncoding RNAs and LRRFIP1 Regulate TNF Expression

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Noncoding RNAs and LRRFIP1 regulate TNF expression.

Noncoding RNAs have been implicated in the regulation of expression of numerous genes; however, the mechanism is not fully understood. We identified bidirectional, long noncoding RNAs upstream of the TNF gene using five different methods. They arose in a region where the repressors LRRFIP1, EZH2, and SUZ12 were demonstrated to bind, suggesting a role in repression. The noncoding RNAs were polya...

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ژورنال

عنوان ژورنال: The Journal of Immunology

سال: 2014

ISSN: 0022-1767,1550-6606

DOI: 10.4049/jimmunol.1302063